What does it consist of?
Egg donation is indicated when the chances of getting a pregnancy using one’s own oocytes is very low or its use is impossible due to the absence of the same or some other conditions that contraindique its use. It consists of in vitro fertilisation in which the ova are derived from a donor. Once fertilized in the laboratory, the procedure is the same as in any IVF. The embryos are cultured for a few days and then transferred to the woman’s uterus.
In Next Fertility ProCrea, thanks to a network of international excellence in assisted reproduction, we offer couples comprehensive support in the diagnostic and therapeutic process in cases where there is an indication to resort to egg donation. Thanks to the collaboration started with the Next Fertility Spain Group in Spain where the donors are recruited and the blastocysts obtained, and the Le Betulle center in Appiano Gentile (Como – Italy), where the embryo transfer is carried out, our clinic is able to support the couple or patients throughout the entire journey.
All donors come from the Next Fertility Spain Group in Spain and undergo an exhaustive series of medical analyses, and genetic, and psychological tests before being admitted.
According to the origin of the seminal sample:
- Egg donation with the couple’s sperm. The sperm comes from a seminal sample from the patient’s partner.
- Egg donation with donor sperm. The semen comes from a gamete bank.
When is it indicated?
- Advanced maternal age.
- Early menopause or premature ovarian failure.
- Absence of ovaries: congenital or after surgical removal.
- Repeated failure of other assisted reproduction techniques.
- Contraindication of the use of own eggs, by hereditary genetic disease, capable of being transmitted to the offspring and that cannot be avoided by the use of Embryonic Genetic Diagnostic Techniques (PGT).
Donor selection at Next Fertility Spain in Spain
This is done, according to the phenotypic characteristics of the recipient of the eggs, taking into account their blood type, we can also offer the opportunity to perform a “genetic matching” (genetic compatibility test), reducing even more the possibilities of transmission of a genetic disease to offspring, since all our donors undergo a comprehensive series of clinical, genetic and psychological tests.
Preparation of the seminal sample at Next Fertility Spain in Spain
It is necessary to prepare the semen sample so that it has the ability to fertilize the egg, in addition to achieving an optimal concentration of mobile sperm.
The sperm sample is obtained by the male by simple masturbation, in his home or in our center, the same day of the insemination or can be previously cryopreserved. In cases where the use of donor semen is indicated, this sample will always be frozen and stored in our semen bank. In both cases, our biologists will treat it in the laboratory with a process known as sperm training, so that we can select the sperm with the best mobility.
Fertilization and culture at Next Fertility Spain in Spain
Our embryologists perform fertilization through a technique called ICSI (Intracytoplasmic sperm injection). It consists of the selection of a single sperm for each egg that is microinjected into it. It is a very precise technique that favors the fusion of the nuclei of the male gamete with the female. Fertilized embryos must be kept in culture for 5-7 days. And during this time, they will develop until they reach the blastocyst stage.
Time-lapse technology is used in the Next Fertility Spain laboratories located in Spain, which allows real-time monitoring of the evolution of embryonic development. In this way, the morpho-kinetic changes that occur are evaluated in a very exhaustive way and this allows the evolutionary stage of the embryos/blastocysts to be monitored.
The blastocysts formed will be cryopreserved until the day of the embryo transfer. In case of embryo transfer to the Italian partner centre, they will be transported by authorized courier.
Endometrial preparation at Next Fertility ProCrea
The objective of this phase is to prepare the endometrium of the patient to maximize the possibilities of embryo implantation. It is performed with the administration of estrogen and progesterone preparations, which contribute to the correct development of the endometrium, which is the layer of the uterus where the embryo will implant and the future baby will develop during its intrauterine life.
During this phase ultrasound checks and hormonal determinations are made to check the correct preparation of the endometrium.
Embryo transfer at the Italian Collaborative Medical Center
The embryo will be transferred into the uterine cavity.
The transfer is carried out with an embryo in the embryo/blastocyst stage (about 3-5/6 days of embryonic life) and is carried out in the Italian partner centre, using a thin transfer catheter.
It is a completely painless procedure that does not require hospitalization.
After the “beta-waiting” period (14-15 days after insemination), a blood pregnancy test will be done. We will look for the presence of the hormone β-hCG (human chorionic gonadotropin), which is the hormone produced by the embryo after its implantation in the endometrium.
If the beta test was positive, two weeks later we will perform an ultrasound, to confirm the presence of “gestational sac” inside the uterus and observe the heartbeat of your future baby.